Former Arsenal midfielder Paul Merson, however, disagrees, saying that anything but a City win would be the death knell for their title aspirations.
"Obviously [it boosted us]", the 27-year-old told Standard Sport when asked about Tottenham's result on Saturday.
Klopp's trophy cabinet - highlighted by two Bundesliga titles with Borussia Dortmund does not compare at the moment - but with his Liverpool side in pole position in the Premier League right now, he has an excellent opportunity to start catching up. There was nothing between them in the standings - they were tied on points after seven games - and plenty of respect was shown on both sides.
Liverpool, who are still unbeaten in the league after hammering Arsenal 4-1 last weekend, head into the clash boasting a seven point lead at the top of the table.
"Of course we did it here in the league and the Champions League - but in the league not many people could touch them".
"We all know, wow, Man City are a fantastic football team and an away game at City - who can go there and think "Probably we will win"?"
"They also took advantage of us being open for the first goal so we have to look at the goal because it was not good enough".
Those will likely be Klopp's tactics again with Liverpool defender Andrew Robertson acknowledging City will "go full throttle into us". "It is a good challenge for us if we're going to reduce the gap". The midfielders they work a lot, they press a lot.
Guardiola said: "I can not figure out that what happened in the past is going to happen in the future".
This fixture in the Premier League last season was won 5-0 by City, though they lost 2-1 at home to Liverpool in the Champions League later in the campaign. The Bianconeri have accumulated 53 points from 17 wins, and have dropped points just twice - against Genoa and Atalanta - and have set a record for then highest tally gained in a calendar year.
"He trained today. Tomorrow we need to have another check in the morning, but he's much better", said Guardiola in his pre-match news conference.
But Guardiola is said to have identified where his players can hurt Liverpool in their crunch showdown. "They're unsafe, I mean it". "That's the situation, so we will see what we do with that".