Fulham's problems at the back look like an open invitation to the Liverpool front three of Mo Salah, Roberto Firmino and Sadio Mane, who between them have led the way to Klopp's side scoring at least three goals in seven of their 10 home games against teams outside the big six in 2018.
He wrote in his column in the official matchday programme: "We come into today's game in a very healthy position in our domestic campaign, albeit I am not immune to some of the debate and discussion surrounding our current form or level of performance".
Asked about Van Dijk's form ahead of Liverpool's clash with Fulham, Klopp replied: 'I am really happy with him.
"That is in a year when our competitors are the champions of last year, two years ago and a refreshed Arsenal, a more experienced Tottenham, who have a similar number of points we have, and Manchester United turning around".
Klopp also pointed out that it is going to take something extra special for any other club to snatch the league title from Guardiola and co.
The German added: "Trent is important to the way we play".
City have to play Manchester United at home, Chelsea face a hard trip to Crystal Palace, and Liverpool host the bottom-of-the-table Fulham on Sunday noontime kick-off.
'He has qualities like Joe [Gomez] has, like Dejan [Lovren] has, like Joel [Matip] has, so that is really good for us. "We have to build on our situation, we have to get better, to get more confidence out of the season".
"Now we have to react for us in the right way, not only on Sunday, but in general". "But we have to enjoy our football as well exactly in the moment because it was, so far, pretty successful".
"I was surprised to be honest because I didn't think that I would start as good as I did, but it's only a positive thing when you start good [straight away]".
But Klopp bristled at suggestions Liverpool should thrash the west Londoners. These are a group of players who embody the best values of football when it comes to finding the ideal mix of entertainment but also a winning mentality. I'm not sure how many games you watch over 90 minutes.
"I would really be an idiot", he said.
Jurgen Klopp has confirmed that Jordan Henderson, Naby Keita and Joe Gomez are all available after minor injury setbacks. "A few people think I am, but not that much if I would talk about goal difference before that game".