A victory would extend Liverpool's lead atop to the group standings, and a tie in the other Group C game - Napoli versus PSG - would leave Liverpool in an nearly unassailable position to progress with just two games remaining.
Red Star Belgrade produced one of the biggest upsets of this season's Champions League by beating Liverpool 2-0 on Tuesday (Wednesday NZT), reviving memories of their time as one of Europe's top football teams.
The Swiss national footballer transferred to Liverpool from Stoke City in the pre-season transfer window and has impressed club manager Jurgen Klopp, bagging a goal and two assists from seven appearances so far this season.
Two first half goals from a €300,000 signing Milan Pavkov, the 24-year-old scoring his first European goals in only his 11th appearance, were enough to beat the off-colour Reds. The Reds have to play PSG and Napoli in their final two games, and they'll likely need at least four points to feel good about their chances. "We have to do better because we can do better, but tonight it is too late", said Liverpool boss Jurgen Klopp.
"He's a wonderful player but in the past nine of his appearances for Liverpool he has scored once - against Red Star Belgrade - and not managed a single assist".
Red Star are expected to be without Vujadin Savic due to injury but Marko Marin is set to return to the squad.
"The boys are very disappointed, I'm very disappointed and we have to do better".
"We can't be letting teams get a start on us like we did tonight".
'Napoli found it tough when they came here and we knew it was going to be a tough place to come.
"We lost our mojo in the game, not in general". For many, this type of performance and result has been coming and it's ensured they will have to qualify from Group C the hard way.
There was to be no way back for Liverpool as the Red Star fans celebrated a famous victory.
However, Red Star is a different proposition at the home and a record of 33 games undefeated in all competitions is some achievement.