Cormier had a quick takedown in the first round and turned in a dominant yet tiresome effort to easily take the round.
Cormier's Olympic-level wrestling proved too much for the heavy hitting Lewis.
Cormier, who also holds the light heavyweight crown, made quick work of an overmatched fellow American Lewis with a rear naked choke in the middle of the second round.
After the fight, Cormier was asked about his expected bout against Lesnar and told the champion to bring the Universal title with him so he can feel like a "WWE Superstar".
"I believe that if I didn't go through stuff that I went through in my past, I wouldn't be as successful like I am now here today".
It was arguably one of the most straightforward wins of the 39-year-old's recent UFC career, as he extended his undefeated record as a heavyweight.
Jones' comments were put to Cormier in the post-fight press conference and he didn't shy away from lambasting his rival over his failed drug tests, the most recent of which detected traces of the banned anabolic steroid Turainbol in his system.
As far as Brock's WWE career goes, he's now being advertised for a Champion vs.
"Bring that belt with you when you come to my house", said Cormier, who has vowed to retire at age 40.
Cormier will now reportedly fight former UFC heavyweight champion Brock Lesnar in 2019.
Lesnar is now in the USADA testing pool and will be clear to return to the octagon in early January.
"The Black Beast" slips to 21-6 overall (with 1 no contest), and saw a three-fight win streak snapped. Lewis opened with a body shot to Cormier and then followed it up with another that backed Cormier up.
Lewis landed a nice combo 30 seconds into the second round and even tried a switch kick as he stepped up the aggression. The co-headliner saw a middleweight barnburner between Chris Weidman and "Jacare" Souza, with the Brazilian jiu-jitsu legend knocking out the former champ.