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Messi had to be subbed out after 26 minutes and was replaced by Ousmane Dembele with Barcelona up 2-0.

It was a ridiculous 15 minutes for Lionel MESSI against Sevilla as he scored, assisted and got injured. His injury keeps him out of the upcoming games against Inter Milan and Real Madrid, as well as others in the next three weeks.

After Sunday's clasico, Messi also stands to miss a Copa del Rey match against Cultural Leonesa, the return leg against Inter and league contests with Rayo Vallecano and Real Betis leading up to the next worldwide break. "We know what he can give to us, what it means to the opposition when Leo's on our team".

Messi's absence from the biggest match in Spanish football is a shame.

But Ernesto Valverde could not hide his concern over the prolonged absence of his skipper.

The Argentine is now nearly certain to miss Wednesday's Champions League clash with Inter Milan, and will also be a huge doubt for El Clasico next weekend.

Vaclik kept out a Coutinho effort in the 52nd minute after a low-key start to the second period, before Luis Suarez struck wide of the post from distance two minutes later.

The three-week injury assessment means Messi will likely return in time for the club's clash with Atletico Madrid at the end of November, which follows an global break.

Messi doubled the advantage, racing clear on the counter-attack before jinking inside and curling into the bottom corner with his left foot.

Pablo Sarabia pulled one back for Sevilla, but Ivan Rakitic restored the hosts' three-goal advantage.

The victory saw Barcelona end a run of four domestic games without victory, and capitalise on defeat earlier in the day for Madrid.

Barcelona, sitting at the top of the table, are now four points above fifth-placed Real Madrid ahead of their showdown next weekend.

Asked about rumours that Lopetegui could be sacked, Sergio Ramos replied: 'I always said that manager changes are never good for anyone.