Koeman later revealed that the medical staff of Liverpool and the Dutch national team had reached an agreement for Van Dijk to only play in the UEFA Nations League clash with Germany.
Klopp described the new competition as "senseless" prior to the recent global break and elaborated on his opinion at a news conference on Friday afternoon.
Liverpool could face the setback of losing Sadio Mane for a few weeks along with other injury scares after the pacy winger broke his left thumb while on global duty with Senegal.
At his pre-match press conference, Klopp said: "I'm pretty sure Naby will not be available".
"The Nations League is a good idea but do it in another sport". Where is the rest? "That is all I was talking about".
Salah and Van Dijk withdrew from their national teams over the worldwide break amid fitness concerns, but trained at Melwood on Thursday afternoon.
Mane underwent an operation on Wednesday on his fractured thumb, sustained during Senegal's win over Sudan on Saturday.
Keita, meanwhile, was pictured being carried off the pitch by a team-mate during Guinea's draw against Rwanda on Tuesday after apparently suffering a hamstring injury.
He said: "One-and-a-half weeks ago everybody was quite happy or satisfied with the situation; one-and-a-half weeks later, we miss a few players. That's it, pretty much".
"I use the word "trap". However the Reds are undefeated and will see this weekend as a glorious opportunity to add three points to the title challenge.
"They had more possession against Tottenham, maybe people are not interested in that but it's a big step".