La Nuova Sardegna said the 57-year-old was headed to a film set on Tuesday when his motorbike was hit by a auto.
Private media firm Mediaset, citing gossip magazine Chi, said the accident occurred near Costa Corallina, in the province of Olbia.
According to the site, George was said to be hit by a auto which suddenly changed direction at a spot close to a hotel. The photo showed the car's windscreen smashed.
Clooney was taken to a hospital and the injuries are not believed to be serious, according to La Nuova.
A fire extinguisher can be seen on the road but no people are visible.
Clooney and his wife Amal are staying in Sardinia for the summer as George films his new TV series Catch 22, which stars Irish comedian David McSavage. Authorities say that Clooney was not seriously injured and confirm he was released from the hospital a short time later.
The US actor is directing, producing and starring in the six episode miniseries based on Joseph Heller's famous novel.
Calls and emails to Clooney's spokesman in regards to the accident weren't immediately returned, according to Associated Press. Clooney fell off the scooter and slammed into the windshield of the Mercedes.