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For now, it is back to the drawing board for Ronaldo and Portugal, as sights turn to the European Championships in two years' time, and possibly one last World Cup for Ronaldo in 2022.

That "look" at an opponent before challenging for an aerial ball wins him countless fouls and loose balls, allowing Uruguay to get their shape back as they come under the inevitable pressure their style permits.

"I am sure he will. Cristiano still has a lot to give to the game", Santos said when asked if he felt his captain would carry on representing his country.

Uruguay coach Oscar Tabarez was complimentary of Ronaldo and the rest of the Portugal squad, noting several times Uruguay will be facing the reigning champions of Europe. There is not a single player that can contain him there.

The good news for Tabarez is that all his players are fit and raring to go.

While Suarez seemed to play down or avoid questions about Ronaldo, it's clear Uruguay must continue to have the tightest defence in the tournament to keep Ronaldo and others under control. Having Gimenez back will solidify Uruguay's defence.

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Fernando Muslera, who recently picked up his 100th cap, will start in goal as usual.

But his fitness will now be a major worry for Uruguay, who showed in this game that they have the credentials to go all the way in Russian Federation - if El Matador is healthy. Uruguay's full-backs, Diego Laxalt at the left and Martin Caceres at the right, were alert in dealing with Guerreiro and Jao Mario on the left and Bernado and substitute Ricardo Quaresma on th right.

Uruguay were quite comfortable, keeping the Portuguese at bay in the first half with constant running and tackling from Lucas Torreira, Matias Vecino, and Nahitan Nandez. Torreira impressed in Uruguay's final group game - both defensively and in attack - and he could retain his spot in the starting lineup.

Cavani had given Uruguay the lead with a header into the top corner after a cross by Luis Suarez in the seventh minute.

Note: This article was updated after the starting lineups were announced.