De Bruyne has said that they aren't comparable as players, but admitted that Salah's record speaks for itself.
"It's probably the most complete [season I've had]", he told the media ahead of the first leg of the Champions League quarter-final tie with Liverpool.
But Salah's total of 37 goals in 42 appearances this season threatens to deprive De Bruyne of individual honours to go with City's trophy haul.
The PFA Player of the Year award is likely to come down to the aforementioned duo, and it seems De Bruyne had no second thoughts about his nomination.
"At Chelsea, he didn't play too much but in Roma he was incredible every game he created a lot of chances but sometimes missed", Guardiola said Tuesday.
Life under Jose Mourinho hadn't proven to be great for either of them as they just simply didn't get games, and now, an interview with De Bruyne has shed some light on how things were. I think if the coach wants to speak with you then you just do it.
"He's up there with [Harry] Kane, me and David [Silva]".
'Maybe a lot of people are picking up on it now, but I'm not really the type of person who thinks about that. "I don't think it's disrespectful".
"He is a guy who is never injured and a guy who always wants to play and has more energy to keep going".
"In Chelsea, he didn't play too much, but in Roma he was awesome", said Guardiola.
De Bruyne committed his future at the Etihad in January by signing a six-year contract worth £280,000 a week.
"It would help us if we win it against United".
"There is nearly no game where my standard has dropped, so I have been very constant".
"I know the way we play is flawless for Liverpool", Guardiola said of his team's expansive style, "because they're a team that attack that space unlike any other team in the world, especially with Mo Salah, Firmino. Every time he shoots he scores", Hamman said.
They return to the scene of their only league defeat this season on Wednesday, with Jurgen Klopp's side scoring three goals in the space of eight minutes before surviving a late scare to triumph 4-3 on home turf.